RESEARCH
The Stroupe Group studies microbial sulfur reduction. Cells need reduced sulfur for biomass formation and as a redox buffer for survival in oxidizing environments.

SULFITE REDUCTASE


In Escherichia coli, sulfite reductase is a two-component oxidoreductase that moves six
electrons from three NADPH molecules to reduce sulfite to sulfide for building biomass. We are interested in understanding how the two subunits interact and undergo dramatic conformational changes to elicit such a large volume electron transfer. We use a combination of X-ray crystallography, cryo-EM, and small angle neutron scattering to study this unique enzyme.
SIROHEME SYNTHASE
