Research Articles

D. T. Murray, K. L. Weiss, C. B. Stanley, G. Nagy, and M. E. Stroupe. Small-angle neutron scattering solution structures of NADPH-dependent sulfite reductase. JSB. 2021. IN PRESS

J. Rai, M. D. Parker, H. Huang, S. Choy, H. Ghalei, M. C. Johnson, K. Karbstein, M. E. Stroupe. An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7. RNA. 2021 Feb;27(2):221-233. doi: 10.1261/rna.077610.120. Epub 2020 Nov 20. PMID: 33219089

J. M. Pennington, M. Kemp, L. McGarry, Y. Chen, M. E. Stroupe. Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nat Commun. 2020 Feb 13;11(1):864. doi: 10.1038/s41467-020-14722-1.

M. Kopylov, T. M. Jackson, and M. E. Stroupe. Bulged and Canonical G-Quadruplex Conformations Determine NDPK Binding Specificity. Molecules. 2019. May 23;24(10):1988. doi: 10.3390/molecules24101988.

A. M. Tavolieri, D. T. Murray, I. Askenasy, J. M. Pennington, L. McGarry, C. B. Stanley, M. E. Stroupe. NADPH-dependent sulfite reductase flavoprotein adopts an extended conformation unique to this diflavin reductase. J Struct Biol. 2019 Feb 1;205(2):170-179. doi: 10.1016/j.jsb.2019.01.001.

M. R. Cepeda, L. McGarry, J. M. Pennington, J. Krzystek, M. E. Stroupe. The role of extended Fe4S4 cluster ligands in mediating sulfite reductase hemoprotein activity. Biochim Biophys Acta Proteins Proteom. 2018 Sep;1866(9):933-940. doi: 10.1016/j.bbapap.2018.05.013.


I. Askenasy, D. T. Murray, R. M. Andrews, V. N. Uversky, H. He, M. E. Stroupe. Structure-Function Relationships in the Oligomeric NADPH-Dependent Assimilatory Sulfite Reductase. Biochemistry. 2018 Jul 3;57(26):3764-3772. doi: 10.1021/acs.biochem.8b00446.


M. C. Johnson, M. Sena-Velez, B. K. Washburn, G. N. Platt, S. Lu, T. E. Brewer, J. S. Lynn, M. E. Stroupe, K. M. Jones. Structure, proteome and genome of Sinorhizobium meliloti phage ΦM5: A virus with LUZ24-like morphology and a highly mosaic genome. J Struct Biol. 2017 Dec;200(3):343-359. doi: 10.1016/j.jsb.2017.08.005.


M. C. Johnson*, H. Ghalei*, K. A. Doxtader, K. Karbstein, and M. E. Stroupe, 2017. Heterogeneity in Pre-40S Ribosomes. Structure. doi:10.1371/journal.pbio.1002480.


S. Khoshnevis, I. Askenasy, M. C. Johnson, M. D. Dattolo, C. L. Young-Erdos, M. E. Stroupe, and K. Karbstein, 2016. The DEAD-box Protein Rok1 Orchestrates 40S and 60S Ribosome Assembly by Promoting the Release of Rrp5 from Pre-40S Ribosomes to Allow for 60S Maturation. PLoS Biology. doi:10.1371/journal.pbio.1002480.

Johnson, M. C., Tatum, K. B., Lynn, J. S., Brewer, T. E., Washburn, B. K., Stroupe, M. E., & Jones, K. M. (2015). Sinorhizobium meliloti phage ΦM9 defines a new group of T4-superfamily phages with unusual genomic features, but a common T=16 capsid. J. Virol., 10945-10958. doi:10.1128/JVI.01353-15.


I. Askenasy*, J. M. Pennington*, Y. Tao, A. G. Marshall, N. L. Young, W. Shang, and M. E. Stroupe. 2015. The N-terminal Domain of Escherichia coli Assimilatory NADPH-Sulfite Reductase Hemoprotein is an Oligomerization Domain that Mediates Holoenzyme Assembly. J. Biol. Chem., 290, 19319-19333. doi:10.1074/jbc.M115.662379.

H. Ghalei, F. X. Schaub, J. R. Doherty, Y. Noguchi, W. R. Roush, J. L. Cleveland, M. E. Stroupe, and K. Karbstein. 2015. J. Cell Biol., 208, 745-759. doi: 10.1083/jcb.201409056.

M. Kopylov, H. W. Bass, and M. E. Stroupe. 2015. The Maize (Zea mays L.) nucleoside diphosphate kinase 1 (ZmNDPK1) gene encodes a human NM23-H2 homolog that binds and stabilizes G-quadruplex DNA. Biochemistry, 54, 1743-1757. doi:10.1021/bi501284.

C. M Andorf, M. Kopylov, D. Dobbs, K. E. Koch, M. E. Stroupe, C. J. Lawrence, and H. W. Bass. 2014. G-quadruplex (G4) motifs in the maize (Zea mays L.) genome are enriched at specific locations in thousands of genes coupled to energy status, hypoxia, low sugar, and nutrient deprivation. J. Genet. Genomics. 41(12):627-47 doi:10.1016/


M. E. Stroupe*, T. Brewer, D. R. Sousa, and K. M. Jones. 2014. The structure of Sinorhizobium meliloti phage ΦM12, which has a novel T=19l triangulation number and is the founder of a new group of T4-superfamily phages. Virology, 450-451:205-212. doi:10.1016/j.virol.2013.11.019.


T. Brewer, M. E. Stroupe, K. M. Jones. 2014 The genome, proteome and phylogenetic analysis of Sinorhizobium meliloti phage ΦM12, the founder of a new group of T4-superfamily phages. Virology, 450-451: 84-97 doi: 10.1016/j.virol.2013.11.027.


D. R. Sousa, S. M. Stagg, and M. E. Stroupe. 2013. Cryo-EM structures of the Actin:Tropomyosin filament reveal the mechanism for the transition from C- the M-state. J, Mol. Biol., 425(22):4544-55. doi: 10.1016/j.jmb.2013.08.020


K. W. Smith and M. E. Stroupe. 2012. Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer. Biochemistry, 51(49):9857-68. doi: 10.1021/bi300947a


M. E. Stroupe, C. Xu, B. J. Goode, and N. Grigorieff. 2009. Actin filament labels for localizing protein components in large complexes viewed by electron microscopy. RNA, 15:244-248. doi: 10.1261/rna.1313609.


Sache, C., J. Z. Chen, P. D. Coureux, M. E. Stroupe, M. Fändrich, and N. Grigorieff. 2007. High-resoluion electron microscopy of helical specimens: a fresh look at tobacco mosaic virus. JMB. 3:812-835. doi: 10.1016/j.jmb.2007.05.088.


M. E. Stroupe*, T. Ø. Tange*, D. R. Thomas, M. J. Moore, N. Grigorieff (2006). “The three dimensional architecture of the EJC core.” JMB, 4, 743-9. doi: 10.1016/j.jmb.2006.05.049.


T. Shibuya, T. Ø. Tange, M. E. Stroupe and M. J. Moore (2006). “Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.” RNA, 3, 360-374. doi: 10.1261/rna.2190706.

W. B. Greenleaf, J. J. Perry, A. S. Hearn, D. E. Cabelli, J. R. Lepock, M. E. Stroupe, J. A. Tainer, D. S. Silverman (2004). “Role of hydrogen bonding in the active site of human manganese superoxide dismutase.” Biochemistry, 22, 7038-7045. doi: 10.1021/bi049888k.

M. E. Stroupe, H. K. Leech, D. S. Daniels, M. J. Warren, and E. D. Getzoff (2003). “CysG structure reveals tetrapyrrole- binding features and novel regulation of siroheme biosynthesis.” Nat. Struct. Bio., 10, 1064-1073. doi: 10.1038/nsb1007.

A. S. Hearn, M. E. Stroupe, D. E. Cabelli, C. A. Ramilo, J. P. Luba, J. A. Tainer, H. S. Nick, and D. N. Silverman (2003). “Catalytic and Structural Effects of Amino Acid Substitution at Histidine 30 in Human Manganese Superoxide Dismutase: Insertion of Valine Cγ into the Substrate Access Channel.” Biochemistry, 10, 2781-9. doi: 10.1021/bi0266481.


M. E. Stroupe (2002). “Making and Using Siroheme: the x-ray Crystallographic Structures of Siroheme Synthase of Sulfite Reductase” thesis.


A. S. Hearn, M. E. Stroupe, D. E. Cabelli, J. R. Lepock, J. A. Tainer, H. S. Nick, and D. N. Silverman (2001). Kinetic analysis of product inhibition in human manganese superoxide dismutase. Biochemistry, 40, 12051-8. doi: 10.1021/bi011047f.


V. J. Leveque, M. E. Stroupe, J. R. Lepock, D. E. Cabelli, J. A. Tainer, H. S. Nick, and D. N. Silverman (2000). Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis. Biochemistry, 39, 7131-7. doi: 10.1021/bi9929958.


Review articles and book chapters

I. Askenasy, M. E. Stroupe. "The Siroheme-[4Fe-4S] Coupled Center." Met Ions Life Sci. 2020 Mar 23;20. doi: 10.1515/9783110589757-016. PMID: 32851831

M. E. Stroupe and M. Warren. "Siroheme Assembly and Insertion into Nitrite and Sulfite Reductase" Encyclopedia of Inorganic and Bioinorganic Chemistry. Wiley. 2017.

M. E. Stroupe and E. D. Getzoff. “The role of siroheme in sulfite and nitrite reductases” in Tetrapyrroles: their birth, life, and death. ed. MJ Warren and A Smith. Landes Bioscience. 2005.


M. E. Stroupe and E. D. Getzoff. “Sulfite Reductase Hemoprotein” in Handbook of Metalloproteins. ed. 1. Messerschmidt, R. Huber, T. Poulos, and K. Wieghardt. John Wiley and Sons, Ltd. Chichester. 2001. ISBN-13: 978-0471627432


M. E. Stroupe, M. Didonato, and J. A. Tainer. “Manganese Superoxide Dismutase” in Handbook of Metalloproteins. ed. 1. Messerschmidt, R. Huber, T. Poulos, and K. Wieghardt. John Wiley and Sons, Ltd. Chichester. 2001. ISBN-13: 978-0471627432.